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Antimicrobial Agents and Chemotherapy, July 2007, p. 2324-2328, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01502-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Multicopy bla_OXA-58 Gene as a Source of High-Level Resistance to Carbapenems in Acinetobacter baumannii

Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanitá, Rome Italy,¹ Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Université Paris XI, K.-Bicêtre, France²

Received 29 November 2006/ Returned for modification 20 January 2007/ Accepted 11 April 2007

The mechanisms at the origin of heterogeneous carbapenem resistance levels observed among Acinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase gene bla_OXA-58 but showed variable levels of resistance to carbapenems. Analysis of sequences surrounding the bla_OXA-58 gene showed genetic variability, with the presence in several isolates of multiple copies of the bla_OXA-58 gene; this extra copy number was likely related to an IS26-mediated transposition or recombination process.

Published ahead of print on 16 April 2007.

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