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Antimicrobial Agents and Chemotherapy, July 2007, p. 2324-2328, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01502-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Multicopy blaOXA-58 Gene as a Source of High-Level Resistance to Carbapenems in Acinetobacter baumannii{triangledown}

Alessia Bertini,1 Laurent Poirel,2 Sandrine Bernabeu,2 Daniela Fortini,1 Laura Villa,1 Patrice Nordmann,2 and Alessandra Carattoli1*

Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanitá, Rome Italy,1 Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Université Paris XI, K.-Bicêtre, France2

Received 29 November 2006/ Returned for modification 20 January 2007/ Accepted 11 April 2007

The mechanisms at the origin of heterogeneous carbapenem resistance levels observed among Acinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase gene blaOXA-58 but showed variable levels of resistance to carbapenems. Analysis of sequences surrounding the blaOXA-58 gene showed genetic variability, with the presence in several isolates of multiple copies of the blaOXA-58 gene; this extra copy number was likely related to an IS26-mediated transposition or recombination process.

* Corresponding author. Mailing address: Department of Infectious, Parasitic, Immune-Mediated Diseases, Istituto Superiore di Sanitá, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39-06-49903128. Fax: 39-06-49387112. E-mail: alecara{at}iss.it

{triangledown} Published ahead of print on 16 April 2007.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2324-2328, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01502-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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