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Antimicrobial Agents and Chemotherapy, July 2007, p. 2591-2593, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01562-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of CG400549, a Novel FabI Inhibitor, against Recently Isolated Clinical Staphylococcal Strains in Korea{triangledown}

Jong Hwa Yum,1,2,3 Chang Ki Kim,1,2 Dongeun Yong,1,2,3 Kyungwon Lee,1,2,3* Yunsop Chong,1,2 Cheol Min Kim,4 Jeong Mi Kim,4 Seonggu Ro,4 and Joong Myung Cho4

Department of Laboratory Medicine,1 Research Institute of Bacterial Resistance,2 BK21 Project for Medical Sciences, Yonsei University College of Medicine,3 CrystalGenomics, Inc., Seoul, Korea4

Received 18 December 2006/ Returned for modification 11 January 2007/ Accepted 2 April 2007

The in vitro activities of CG400549, a novel FabI inhibitor, were compared to those of linezolid and commonly used antimicrobials against recent bacterial isolates. CG400549 had an MIC90 of 0.5 µg/ml for Staphylococcus aureus strains and was more potent than either linezolid or vancomycin.

* Corresponding author. Mailing address: Department of Laboratory Medicine, Yonsei University College of Medicine, 134 Shinchondong, Seodaemunku, Seoul 120-752, Korea. Phone: 82-2-2228-2446. Fax: 82-2-313-0908. E-mail: leekcp{at}yumc.yonsei.ac.kr

{triangledown} Published ahead of print on 9 April 2007.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2591-2593, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01562-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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