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Antimicrobial Agents and Chemotherapy, July 2007, p. 2600-2604, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00212-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Selective Inhibition of Porcine Endogenous Retrovirus Replication in Human Cells by Acyclic Nucleoside Phosphonates{triangledown}

Minyi Shi,1,2 Xin Wang,2 Erik De Clercq,3 Sonshin Takao,1 and Masanori Baba2*

Frontier Science Research Center, Kagoshima University, Kagoshima 890-8544, Japan,1 Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan,2 Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium3

Received 13 February 2007/ Returned for modification 29 March 2007/ Accepted 24 April 2007

Several anti-human immunodeficiency virus type 1 reverse transcriptase inhibitors were evaluated for their antiviral activities against porcine endogenous retrovirus in human cells. Among the test compounds, zidovudine was found to be the most active. The order of potency was zidovudine > phosphonylmethoxyethoxydiaminopyrimidine = phosphonylmethoxypropyldiaminopurine > tenofovir ≥ adefovir > stavudine.

* Corresponding author. Mailing address: Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan. Phone: 81 99-275-5931. Fax: 81 99-275-5932. E-mail: m-baba{at}vanilla.ocn.ne.jp

{triangledown} Published ahead of print on 30 April 2007.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2600-2604, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00212-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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