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Antimicrobial Agents and Chemotherapy, July 2007, p. 2605-2607, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00125-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Neutralizing Viruses in Suspensions by Copper Oxide-Based Filters{triangledown}

Gadi Borkow,1,2* Robert W. Sidwell,3 Donald F. Smee,3 Dale L. Barnard,3 John D. Morrey,3 Humberto H. Lara-Villegas,1,{dagger} Yonat Shemer-Avni,4 and Jeffrey Gabbay2

Ruth Ben-Ari Institute of Clinical Immunology, Kaplan Medical Center, Rehovot 76100, Israel,1 Cupron, Inc., POB 10973, Greensboro, NC 27404,2 Institute for Antiviral Research, Utah State University, Logan, Utah 84322-5600,3 Department of Virology, Faculty of Health Sciences, Soroka Academic Medical Center, Beer-Sheva 84105, Israel4

Received 28 January 2007/ Returned for modification 15 March 2007/ Accepted 24 April 2007

We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media. Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses found in filterable suspensions.

* Corresponding author. Mailing address: Cupron, Inc., Hameyasdim 44, Kfar Gibton 76910, Israel. Phone: 972-546-611287. Fax: 972-8-9491254. E-mail: gadi{at}cupron.com

{triangledown} Published ahead of print on 30 April 2007.

{dagger} Present address: Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo León, Mexico.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2605-2607, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00125-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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