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Antimicrobial Agents and Chemotherapy, July 2007, p. 2615-2617, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00240-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Efficacy of Fluoroquinolones against Leptospira interrogans in a Hamster Model{triangledown}

Matthew E. Griffith,* James E. Moon, Erica N. Johnson, Kyra P. Clark, Joshua S. Hawley, Duane R. Hospenthal, and Clinton K. Murray

Infectious Disease Service, Brooke Army Medical Center, Fort Sam Houston, Texas

Received 16 February 2007/ Returned for modification 21 March 2007/ Accepted 24 April 2007

Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

* Corresponding author. Mailing address: Infectious Disease Service, MCHE-MDI, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234. Phone: (210) 916-5554. Fax: (210) 916-0388. E-mail: matthew.griffith{at}amedd.army.mil

{triangledown} Published ahead of print on 30 April 2007.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2615-2617, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00240-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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