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Antimicrobial Agents and Chemotherapy, July 2007, p. 2618-2620, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01516-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Association between embB Codon 306 Mutations and Drug Resistance in Mycobacterium tuberculosis{triangledown}

Xin Shen,1,2,3,4 Guo-miao Shen,1,2,3 Jie Wu,4 Xiao-hong Gui,4 Xia Li,1,2,3 Jian Mei,4 Kathryn DeRiemer,5 and Qian Gao1,2,3*

Key Laboratory of Medical Molecular Virology, Shanghai Medical College,1 Institute of Medical Microbiology,2 Institute of Biomedical Sciences, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032,3 Department of TB Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China,4 School of Medicine, University of California, One Shields Avenue, Davis, California 956165

Received 2 December 2006/ Returned for modification 12 March 2007/ Accepted 9 April 2007

embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.

* Corresponding author. Mailing address: Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai, China 200032. Phone: (8621) 5423-7195. Fax: (8621) 5423-7971. E-mail: qgao99{at}yahoo.com

{triangledown} Published ahead of print on 16 April 2007.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2618-2620, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01516-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Starks, A. M., Gumusboga, A., Plikaytis, B. B., Shinnick, T. M., Posey, J. E. (2009). Mutations at embB Codon 306 Are an Important Molecular Indicator of Ethambutol Resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 53: 1061-1066 [Abstract] [Full Text]  
  • Hazbon, M. H., Motiwala, A. S., Cavatore, M., Brimacombe, M., Whittam, T. S., Alland, D. (2008). Convergent Evolutionary Analysis Identifies Significant Mutations in Drug Resistance Targets of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 52: 3369-3376 [Abstract] [Full Text]  
  • Safi, H., Sayers, B., Hazbon, M. H., Alland, D. (2008). Transfer of embB Codon 306 Mutations into Clinical Mycobacterium tuberculosis Strains Alters Susceptibility to Ethambutol, Isoniazid, and Rifampin. Antimicrob. Agents Chemother. 52: 2027-2034 [Abstract] [Full Text]  


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