This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shin, J. H.
Right arrow Articles by Chang, C. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shin, J. H.
Right arrow Articles by Chang, C. L.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, July 2007, p. 2625-2627, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00107-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Prevalence, Characteristics, and Molecular Epidemiology of Macrolide and Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae at Five Tertiary-Care Hospitals in Korea{triangledown}

Jeong Hwan Shin,1,2* Hee Jung Jung,1,2 Hye Ran Kim,1 Joseph Jeong,3 Seok Hoon Jeong,4 Sunjoo Kim,5 Eun Yup Lee,6 Jeong Nyeo Lee,1,2 and Chulhun Ludgerus Chang6,7

Department of Laboratory Medicine,1 Paik Institute for Clinical Research, College of Medicine, Inje University, Busan,2 Department of Laboratory Medicine, College of Medicine, Ulsan University, Ulsan,3 Department of Laboratory Medicine, College of Medicine, Kosin University, Busan,4 Department of Laboratory Medicine, School of Medicine, Gyeongsang National University, Jinju,5 Department of Laboratory Medicine, School of Medicine,6 Medical Research Institute, Pusan National University, Busan, Korea7

Received 24 January 2007/ Returned for modification 21 March 2007/ Accepted 7 May 2007

The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofloxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofloxacin with reserpine was highly specific for efflux screening.

* Corresponding author. Mailing address: Department of Laboratory Medicine, College of Medicine, Inje University, 633-165 Gaegeum-Dong Busanjin-Gu, Busan, 614-110, Korea. Phone: 82-51-890-6475. Fax: 82-51-893-1562. E-mail: jhsmile{at}inje.ac.kr

{triangledown} Published ahead of print on 14 May 2007.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2625-2627, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00107-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»