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Antimicrobial Agents and Chemotherapy, July 2007, p. 2631-2635, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01492-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors{triangledown}

Debra L. Hudson,1,{dagger} Abigail N. Layton,1,{dagger} Terry R. Field,1 Alison J. Bowen,1 Hans Wolf-Watz,2 Mikael Elofsson,3 Mark P. Stevens,1 and Edouard E. Galyov1*

Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom,1 Department of Molecular Biology,2 Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden3

Received 28 November 2006/ Returned for modification 2 February 2007/ Accepted 3 May 2007

Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.

* Corresponding author. Mailing address: Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom. Phone: 44 (0) 1635 578411. Fax: 44 (0) 1635 577237. E-mail: edouard.galyov{at}bbsrc.ac.uk

{triangledown} Published ahead of print on 14 May 2007.

{dagger} These authors contributed equally to this work.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2631-2635, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01492-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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