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Antimicrobial Agents and Chemotherapy, July 2007, p. 2631-2635, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01492-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors

Debra L. Hudson,^1, Abigail N. Layton,^1, Terry R. Field,¹ Alison J. Bowen,¹ Hans Wolf-Watz,² Mikael Elofsson,³ Mark P. Stevens,¹ and Edouard E. Galyov^1*

Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom,¹ Department of Molecular Biology,² Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden³

Received 28 November 2006/ Returned for modification 2 February 2007/ Accepted 3 May 2007

Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.

Published ahead of print on 14 May 2007.

These authors contributed equally to this work.