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Antimicrobial Agents and Chemotherapy, July 2007, p. 2639-2641, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01446-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Safety and Activity of the Immune Modulator HE2000 on the Incidence of Tuberculosis and Other Opportunistic Infections in AIDS Patients{triangledown}

Dwight R. Stickney,1* Zoja Noveljic,2 Armando Garsd,1 Daniel A. Destiche,1 and James M. Frincke1

Hollis-Eden Pharmaceuticals, Inc., San Diego, California,1 Karl Bremmer Hospital, Cape Town, Republic of South Africa2

Received 17 November 2006/ Returned for modification 26 January 2007/ Accepted 20 April 2007

Twenty-five AIDS patients were treated with HE2000, a synthetic adrenal hormone. The drug was well tolerated and safe and reduced both the incidence of tuberculosis coinfection by 42.2% (P < 0.05) and the cumulative incidence of opportunistic infections (P < 0.05). These results warrant further clinical investigation of HE2000.

* Corresponding author. Mailing address: Hollis-Eden Pharmaceuticals, Inc., 4435 Eastgate Mall, Suite 400, San Diego, CA 92121. Phone: (858) 587-9333. Fax: (858) 558-6470. E-mail: dstickney{at}holliseden.com

{triangledown} Published ahead of print on 30 April 2007.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2639-2641, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.01446-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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