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Safety and Activity of the Immune Modulator HE2000 on the Incidence of Tuberculosis and Other Opportunistic Infections in AIDS Patients

Hollis-Eden Pharmaceuticals, Inc., San Diego, California,¹ Karl Bremmer Hospital, Cape Town, Republic of South Africa²

Received 17 November 2006/ Returned for modification 26 January 2007/ Accepted 20 April 2007

Twenty-five AIDS patients were treated with HE2000, a synthetic adrenal hormone. The drug was well tolerated and safe and reduced both the incidence of tuberculosis coinfection by 42.2% (P < 0.05) and the cumulative incidence of opportunistic infections (P < 0.05). These results warrant further clinical investigation of HE2000.

Published ahead of print on 30 April 2007.

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