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Antimicrobial Agents and Chemotherapy, July 2007, p. 2642-2645, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00007-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Sultam Thiourea Inhibition of West Nile Virus{triangledown}

Eric Barklis,1* Amelia Still,1 Mohammad I. Sabri,2 Alec J. Hirsch,3,4 Janko Nikolich-Zugich,3,4 James Brien,3,4 Tenzin Choesang Dhenub,1 Isabel Scholz,1 and Ayna Alfadhli1

Vollum Institute and Department of Molecular Microbiology and Immunology, Oregon Health & Sciences University (OHSU), Portland, Oregon,1 Center for Research on Occupational and Environmental Toxicology and Department of Neurology, OHSU, Portland, Oregon,2 Department of Molecular Microbiology and Immunology and Vaccine and Gene Therapy Institute, OHSU, Portland, Oregon,3 Oregon National Primate Research Center, Beaverton, Oregon4

Received 3 January 2007/ Returned for modification 26 February 2007/ Accepted 11 April 2007

We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 µM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.

* Corresponding author. Mailing address: Vollum Institute and Department of Molecular Microbiology and Immunology, Oregon Health & Sciences University, Mail Code L220, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098. Phone: (503) 494-8098. Fax: (503) 494-6862. E-mail: barklis{at}ohsu.edu

{triangledown} Published ahead of print on 23 April 2007.

Antimicrobial Agents and Chemotherapy, July 2007, p. 2642-2645, Vol. 51, No. 7
0066-4804/07/$08.00+0     doi:10.1128/AAC.00007-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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Copyright © 2007 by the American Society for Microbiology. All rights reserved.