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Antimicrobial Agents and Chemotherapy, August 2007, p. 2855-2860, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.01614-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Extended-Spectrum ß-Lactamases of the CTX-M Type Now in Switzerland{triangledown}

Marie-Frédérique Lartigue,1,{dagger} Catherine Zinsius,1 Aline Wenger,2 Jacques Bille,2 Laurent Poirel,1 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris Sud, 94275 K.-Bicêtre, France,1 Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, CH1011 Lausanne, Switzerland2

Received 27 December 2006/ Returned for modification 2 February 2007/ Accepted 9 April 2007

The epidemiology of clavulanic acid-inhibited extended-spectrum ß-lactamases (ESBLs) was investigated among infection-associated enterobacterial isolates at the University Hospital in Lausanne, Switzerland, from January 2004 to June 2005. Out of 57 nonrepetitive ESBL producers (prevalence rate of 0.7%), 45 produced CTX-M-like ESBLs. CTX-M enzymes were mostly from clonally nonrelated Escherichia coli isolates, from urinary infections and community-acquired infections. Pediatric patients (20 out of 57) accounted for a large number of CTX-M producers. CTX-M-15 was the most frequent CTX-M-type enzyme. The plasmid-located blaCTX-M genes were associated with either ISEcp1 or ISCR1 insertion sequences. This study is the first published report of CTX-M-type ß-lactamases in Switzerland.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 K.-Bicêtre, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.aphp.fr

{triangledown} Published ahead of print on 30 April 2007.

{dagger} Present address: Service de Bactériologie-Hygiène, CHRU Trousseau, UFR Médecine, Université François-Rabelais de Tours, 37000 Tours Cedex, France.

Antimicrobial Agents and Chemotherapy, August 2007, p. 2855-2860, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.01614-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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