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Antimicrobial Agents and Chemotherapy, August 2007, p. 2979-2981, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.01394-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus

Division of Pediatric Infectious Diseases, Department of Pediatrics,¹ Department of Molecular Genetics and Microbiology,² Division of Infectious Diseases and International Health, Department of Medicine,³ Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710⁴

Received 7 November 2006/ Returned for modification 6 January 2007/ Accepted 5 May 2007

Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-ß-D-glucan revealed decreased amounts in the calcineurin A (cnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

Published ahead of print on 14 May 2007.

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