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Antimicrobial Agents and Chemotherapy, August 2007, p. 2979-2981, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.01394-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus{triangledown}

William J. Steinbach,1,2* Robert A. Cramer Jr.,2 B. Zachary Perfect,1 Christina Henn,1 Kirsten Nielsen,2 Joseph Heitman,2,3,4 and John R. Perfect2,3

Division of Pediatric Infectious Diseases, Department of Pediatrics,1 Department of Molecular Genetics and Microbiology,2 Division of Infectious Diseases and International Health, Department of Medicine,3 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 277104

Received 7 November 2006/ Returned for modification 6 January 2007/ Accepted 5 May 2007

Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-ß-D-glucan revealed decreased amounts in the calcineurin A ({Delta}cnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

* Corresponding author. Mailing address: Division of Pediatric Infectious Diseases, Box 3499, Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-3734. Fax: (919) 684-8902. E-mail: stein022{at}mc.duke.edu

{triangledown} Published ahead of print on 14 May 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 2979-2981, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.01394-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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