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Antimicrobial Agents and Chemotherapy, August 2007, p. 2988-2990, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00083-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Identification and Characterization of a New Metallo-ß-Lactamase, IND-5, from a Clinical Isolate of Chryseobacterium indologenes{triangledown}

Mariagrazia Perilli,1 Bibiana Caporale,1 Giuseppe Celenza,1 Cristina Pellegrini,1 Jean Denis Docquier,2 Marilina Mezzatesta,3 Gian Maria Rossolini,2 Stefania Stefani,3 and Gianfranco Amicosante1*

Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, I-67100 L'Aquila,1 Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Università di Siena, I-53100 Siena,2 Dipartimento di Scienze Microbiologiche e Ginecologiche, Università di Catania, I-95124 Catania, Italy3

Received 19 January 2007/ Returned for modification 9 March 2007/ Accepted 20 April 2007

A new natural IND-type metallo-ß-lactamase variant, IND-5, was identified in a clinical isolate of Chryseobacterium indologenes. IND-5 shared 92.8% and 92.4% amino acid homology with IND-1 and IND-3, respectively. Purified enzyme (pI = 8.8, Mr = 25,000) was able to hydrolyze penicillins, some narrow- and expanded-spectrum cephalosporins, and carbapenems but not monobactams.

* Corresponding author. Mailing address: Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di L'Aquila, Biochimica Clinica e Biologia Molecolare Clinica, loc. Coppito, I-67100 L'Aquila, Italy. Phone: 39-0862433455. Fax: 39-0862433433. E-mail: amicosante{at}cc.univaq.it

{triangledown} Published ahead of print on 30 April 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 2988-2990, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00083-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zeba, B., De Luca, F., Dubus, A., Delmarcelle, M., Simpore, J., Nacoulma, O. G., Rossolini, G. M., Frere, J.-M., Docquier, J.-D. (2009). IND-6, a Highly Divergent IND-Type Metallo-{beta}-Lactamase from Chryseobacterium indologenes Strain 597 Isolated in Burkina Faso. Antimicrob. Agents Chemother. 53: 4320-4326 [Abstract] [Full Text]  


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