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Antimicrobial Agents and Chemotherapy, August 2007, p. 3001-3003, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00256-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Changes in qnr Prevalence and Fluoroquinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Enterobacter spp. Collected from 1990 to 2005{triangledown}

Jacob Strahilevitz,1* Dalia Engelstein,1 Amos Adler,1 Violeta Temper,1 Allon E. Moses,1 Colin Block,1 and Ari Robicsek2

Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University, Jerusalem 91120, Israel,1 Department of Medicine, Evanston Northwestern Healthcare, 2650 Ridge Ave., Evanston, Illinois 602012

Received 20 February 2007/ Returned for modification 5 April 2007/ Accepted 21 May 2007

Clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 through 2005 at a tertiary care center were studied for qnr genes. Isolates bearing these genes emerged in the mid-1990s, coinciding with the time of a rapid increase in fluoroquinolone resistance. Sixty percent of these isolates were ciprofloxacin susceptible by CLSI breakpoints.

* Corresponding author. Mailing address: Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein-Kerem, Jerusalem 91120, Israel. Phone: 972-50-894 6353. Fax: 972-2-641 9545. E-mail: jstrahilevitz{at}hadassah.org.il

{triangledown} Published ahead of print on 25 May 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 3001-3003, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00256-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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