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Antimicrobial Agents and Chemotherapy, August 2007, p. 3004-3007, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00167-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Sequencing and Comparative Genomic Analysis of pK29, a 269-Kilobase Conjugative Plasmid Encoding CMY-8 and CTX-M-3 ß-Lactamases in Klebsiella pneumoniae{triangledown}

Ying-Tsong Chen,1* Tsai-Ling Lauderdale,2 Tsai-Lien Liao,1 Yih-Ru Shiau,2 Hung-Yu Shu,3 Keh-Ming Wu,1,4 Jing-Jou Yan,5 Ih-Jen Su,2 and Shih-Feng Tsai1,3,4,6,7

Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan,1 Division of Clinical Research, National Health Research Institutes, Zhunan, Miaoli, Taiwan,2 Genome Research Center, National Yang-Ming University, Taipei, Taiwan,3 Institute of Bioinformatics, National Yang-Ming University, Taipei, Taiwan,4 Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan,5 Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan,6 Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan7

Received 5 February 2007/ Returned for modification 25 March 2007/ Accepted 19 May 2007

A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum ß-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses.

* Corresponding author. Mailing address: Division of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan. Phone: 886-37246166, ext. 35345. Fax: 886-37586459. E-mail: onion{at}nhri.org.tw

{triangledown} Published ahead of print on 25 May 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 3004-3007, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00167-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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