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Antimicrobial Agents and Chemotherapy, August 2007, p. 3011-3013, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00085-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

New Guinea Pig Model of Cryptococcal Meningitis{triangledown}

William R. Kirkpatrick,1* Laura K. Najvar,1 Rosie Bocanegra,1 Thomas F. Patterson,1,2 and John R. Graybill1,2

Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas 78229-3900,1 Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 782842

Received 19 January 2007/ Returned for modification 13 March 2007/ Accepted 3 June 2007

We developed a guinea pig model of cryptococcal meningitis to evaluate antifungal agents. Immunosuppressed animals challenged intracranially with Cryptococcus neoformans responded to fluconazole and voriconazole. Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy.

* Corresponding author. Mailing address: The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229-3900. Phone: (210) 567-4823. Fax: (210) 567-3303. E-mail: kirkpatrick{at}uthscsa.edu

{triangledown} Published ahead of print on 11 June 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 3011-3013, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00085-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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