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Antimicrobial Agents and Chemotherapy, August 2007, p. 3023-3025, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00012-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Resistance-Mediating Plasmodium falciparum pfcrt and pfmdr1 Alleles after Treatment with Artesunate-Amodiaquine in Uganda{triangledown}

Samuel L. Nsobya,1 Christian Dokomajilar,2 Moses Joloba,3 Grant Dorsey,2 and Philip J. Rosenthal2*

Department of Medicine, Makerere University, Kampala, Uganda,1 Department of Medicine, University of California, San Francisco, California,2 Department of Microbiology, Makerere University, Kampala, Uganda3

Received 4 January 2007/ Returned for modification 23 March 2007/ Accepted 31 May 2007

Key parasite polymorphisms were assessed in subjects treated for malaria with artesunate-amodiaquine in Tororo, Uganda. For pfcrt, all of the isolates tested had the CVIET haplotype. For pfmdr1, 86Y and 1246Y were common at baseline and their prevalences were significantly higher in new isolates after therapy, indicating that treatment selected for mutations associated with a decreased response to amodiaquine.

* Corresponding author. Mailing address: Box 0811, University of California, San Francisco, CA 94143. Phone: (415) 206-8845. Fax: (415) 648-8425. E-mail: philip.rosenthal{at}ucsf.edu

{triangledown} Published ahead of print on 11 June 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 3023-3025, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00012-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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