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Antimicrobial Agents and Chemotherapy, August 2007, p. 3026-3029, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00299-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Emergence of KPC-2 and KPC-3 in Carbapenem-Resistant Klebsiella pneumoniae Strains in an Israeli Hospital{triangledown}

Azita Leavitt, Shiri Navon-Venezia, Inna Chmelnitsky, Mitchell J. Schwaber, and Yehuda Carmeli*

Division of Epidemiology and the Laboratory for Molecular Epidemiology and Antibiotic Research, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Received 2 March 2007/ Returned for modification 6 April 2007/ Accepted 4 June 2007

Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and colistin and carried the blaKPC-3 gene, while almost all other clones carried the blaKPC-2 gene. This rapid dissemination of KPC outside the United States is worrisome.

* Corresponding author. Mailing address: Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., Tel Aviv 64239, Israel. Phone: 972 3 692 5644. Fax: 972 3 697 4966. E mail: yehudac{at}tasmc.health.gov.il

{triangledown} Published ahead of print on 11 June 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 3026-3029, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00299-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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