This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Coelho, A. C.
Right arrow Articles by Cotrim, P. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Coelho, A. C.
Right arrow Articles by Cotrim, P. C.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 2007, p. 3030-3032, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00404-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Role of the ABC Transporter PRP1 (ABCC7) in Pentamidine Resistance in Leishmania Amastigotes{triangledown}

Adriano C. Coelho,1 Nadine Messier,2 Marc Ouellette,2 and Paulo C. Cotrim1*

Instituto de Medicina Tropical, Depto. Moléstias Infecciosas e Parasitárias, São Paulo University Medical School, Av. Dr. Enéas de Carvalho Aguiar, 470, 4° andar, São Paulo 05403-900, Brazil,1 Centre de Recherche en Infectiologie du Centre de Recherche du CHUL and Division de Microbiologie, Faculté de Médecine, Université Laval, Québec, Canada2

Received 23 March 2007/ Returned for modification 6 April 2007/ Accepted 14 April 2007

Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp. parasites in the intracellular stage.

* Corresponding author. Mailing address: Instituto de Medicina Tropical, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 470, 4o andar, São Paulo 05403-900, Brazil. Phone: 55-11-306167024. Fax: 55-11-30623622. E-mail: pccotrim{at}usp.br

{triangledown} Published ahead of print on 23 April 2007.

Antimicrobial Agents and Chemotherapy, August 2007, p. 3030-3032, Vol. 51, No. 8
0066-4804/07/$08.00+0     doi:10.1128/AAC.00404-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»