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Antimicrobial Agents and Chemotherapy, September 2007, p. 3361-3363, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00445-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Immunochromatographic Strip Test for Rapid Detection of Nevirapine in Plasma Samples from Human Immunodeficiency Virus-Infected Patients{triangledown}

Tim R. Cressey,1,2 Sawitree Nangola,3 Yardpiroon Tawon,2 Mookda Pattarawarapan,4 Marc Lallemant,1,2 and Chatchai Tayapiwatana3*

Harvard School of Public Health, Harvard University, Boston, MA,1 Program for HIV Prevention and Treatment, UR 174, Institut de Recherche pour le Développement,2 Division of Clinical Immunology, Faculty of Associated Medical Sciences,3 Department of Chemistry, Faculty of Sciences, Chiang Mai University, Chiang Mai, Thailand4

Received 31 March 2007/ Returned for modification 11 May 2007/ Accepted 22 June 2007

We report a novel one-step immunochromatographic strip test for the rapid, qualitative detection of nevirapine in plasma samples from human immunodeficiency virus-infected patients. The sensitivity was 100% (95% confidence interval [95% CI], 97.8 to 100%), and the specificity was 99.5% (95% CI, 97.2 to 99.9%). The limit of detection was 25 ng/ml. Immunochromatographic strip tests are simple, rapid, and cheap assays that could greatly facilitate drug level monitoring in resource-limited settings.

* Corresponding author. Mailing address: Faculty of Associated Medical Sciences, Division of Clinical Immunology, 5th Floor, 110 Inthawaroros Rd., Muang Chiang Mai 50200, Thailand. Phone: 66 81884 5141. Fax: 66 53 9460. E-mail: asimi002{at}chiangmai.ac.th

{triangledown} Published ahead of print on 2 July 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3361-3363, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00445-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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