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Antimicrobial Agents and Chemotherapy, September 2007, p. 3364-3366, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00347-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Innate Protection of Mycobacterium smegmatis against the Antimicrobial Activity of Nitric Oxide Is Provided by Mycothiol{triangledown}

Christopher C. Miller,1,2 Mamta Rawat,3 Todd Johnson,3 and Yossef Av-Gay1*

Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada,1 Pulmonox Medical Inc., Box 1020, Tofield, AB T0B 4J0, Canada,2 Department of Biology, California State University—Fresno, Fresno, California, 937403

Received 14 March 2007/ Returned for modification 16 May 2007/ Accepted 9 July 2007

Nitric oxide (NO) is an efficient antimicrobial agent. A role for mycothiol in protecting mycobacteria from nitrosative damage was revealed by showing that a Mycobacterium smegmatis mutant is sensitive to NO. A direct correlation between NO and mycothiol levels confirmed that mycothiol is important for protecting mycobacteria from NO attack.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, University of British Columbia, 2733 Heather St., Vancouver, BC, Canada V5Z 3J5. Phone: (604) 875 4588. Fax: (604) 875 4013. E-mail: yossi{at}interchange.ubc.ca

{triangledown} Published ahead of print on 16 July 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3364-3366, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00347-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Newton, G. L., Buchmeier, N., Fahey, R. C. (2008). Biosynthesis and Functions of Mycothiol, the Unique Protective Thiol of Actinobacteria. Microbiol. Mol. Biol. Rev. 72: 471-494 [Abstract] [Full Text]  


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