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Antimicrobial Agents and Chemotherapy, September 2007, p. 3385-3387, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00475-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Retapamulin Inhibition of Translation and 50S Ribosomal Subunit Formation in Staphylococcus aureus Cells{triangledown}

W. Scott Champney* and Ward K. Rodgers

Department of Biochemistry and Molecular Biology, J. H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614

Received 6 April 2007/ Returned for modification 7 May 2007/ Accepted 30 May 2007

Retapamulin inhibited protein biosynthesis and cell viability in methicillin-sensitive and methicillin-resistant Staphylococcus aureus organisms. A specific inhibitory effect on 50S ribosomal subunit formation was also found. Pulse-chase labeling experiments confirmed the specific inhibition of 50S subunit biogenesis. Turnover of 23S rRNA was found, with no effect on 16S rRNA amounts.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, J. H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614. Phone: (423) 439-2022. Fax: (423) 439-2030. E-mail: champney{at}etsu.edu

{triangledown} Published ahead of print on 11 June 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3385-3387, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00475-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Siibak, T., Peil, L., Xiong, L., Mankin, A., Remme, J., Tenson, T. (2009). Erythromycin- and Chloramphenicol-Induced Ribosomal Assembly Defects Are Secondary Effects of Protein Synthesis Inhibition. Antimicrob. Agents Chemother. 53: 563-571 [Abstract] [Full Text]  


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