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Antimicrobial Agents and Chemotherapy, September 2007, p. 3388-3390, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00443-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

High Prevalence of Metallo-ß-Lactamase and 16S rRNA Methylase Coproduction among Imipenem-Resistant Pseudomonas aeruginosa Isolates in Brazil{triangledown}

Yohei Doi,1* Angela C. R. Ghilardi,2 Jennifer Adams,1 Doroti de Oliveira Garcia,2 and David L. Paterson1

Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania,1 Instituto Adolfo Lutz, São Paulo, Brazil2

Received 30 March 2007/ Returned for modification 13 May 2007/ Accepted 11 June 2007

Rates of metallo-ß-lactamase and 16S rRNA methylase production were investigated in 51 imipenem-resistant Pseudomonas aeruginosa clinical isolates collected from hospitals in São Paulo, Brazil. Of them, 57% and 75% produced SPM-1 and RmtD, respectively. Of note, 51% produced both enzymes, suggesting that their coproduction is already common in this geographic area.

* Corresponding author. Mailing address: Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh PA 15213. Phone: (412) 648-6401. Fax: (412) 648-6399. E-mail: doiy{at}dom.pitt.edu

{triangledown} Published ahead of print on 18 June 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3388-3390, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00443-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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