Previous Article | Next Article ![]()
Antimicrobial Agents and Chemotherapy, September 2007, p. 3397-3400, Vol. 51, No. 9
0066-4804/07/$08.00+0 doi:10.1128/AAC.01242-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Université de Nantes, Nantes Atlantique Universités, Thérapeutiques Cliniques et Expérimentales des Infections, EA3826, UFR Médecine, Nantes, France,1 Cerexa, Inc., Alameda, California2
Received 4 October 2006/ Returned for modification 28 January 2007/ Accepted 9 June 2007
Using the rabbit endocarditis model, we compared the activity of a new broad-spectrum cephalosporin, ceftaroline, with those of linezolid and vancomycin against methicillin-resistant Staphylococcus aureus. After a 4-day treatment, ceftaroline exhibited superior bactericidal in vivo activity against resistant S. aureus strains and appeared to be the most effective drug against a heterogeneous glycopeptide-intermediate S. aureus strain.
Published ahead of print on 25 June 2007.
This article has been cited by other articles:
Copyright © 2009 by the American Society for Microbiology. For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»