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Antimicrobial Agents and Chemotherapy, September 2007, p. 3401-3403, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.01520-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vivo Efficacy of Moxifloxacin Compared with Cloxacillin and Vancomycin in a Staphylococcus aureus Rabbit Arthritis Experimental Model{triangledown}

Olivier Grossi, Jocelyne Caillon,* Cedric Arvieux, Cedric Jacqueline, Denis Bugnon, Gilles Potel, and Antoine Hamel

Université de Nantes, Nantes Atlantique Universités, Thérapeutiques Cliniques et Expérimentales des Maladies Infectieuses, EA 3826, Faculté de Médecine, Nantes F-44000, France

Received 4 December 2006/ Returned for modification 26 March 2007/ Accepted 7 June 2007

We investigated the efficacies of moxifloxacin, cloxacillin, and vancomycin in a rabbit model of Staphylococcus aureus arthritis. No significant difference between therapeutic regimens was observed after a 7-day treatment. Oral moxifloxacin could be a suitable alternative to standard parenteral therapy for S. aureus arthritis.

* Corresponding author. Mailing address: Laboratoire EA 3826, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France. Phone and fax: (33) 240 41 2854. E-mail: jocelyne.caillon{at}univ-nantes.fr

{triangledown} Published ahead of print on 18 June 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3401-3403, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.01520-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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