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Antimicrobial Agents and Chemotherapy, September 2007, p. 3404-3406, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.01563-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Increasing Ceftriaxone Resistance and Multiple Alterations of Penicillin-Binding Proteins among Penicillin-Resistant Streptococcus pneumoniae Isolates in Taiwan

Cheng-Hsun Chiu,^1,2,* Lin-Hui Su,^2,3, Yhu-Chering Huang,^1,2 Jui-Chia Lai,¹ Hsiu-Ling Chen,¹ Tsu-Lan Wu,^2,3 and Tzou-Yien Lin^1,2

Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital,¹ Chang Gung University College of Medicine,² Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan³

Received 18 December 2006/ Returned for modification 7 February 2007/ Accepted 15 June 2007

The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.

Published ahead of print on 25 June 2007.

C.-H. Chiu and L.-H. Su contributed equally to this work.

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