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Antimicrobial Agents and Chemotherapy, September 2007, p. 3413-3415, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.01571-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Activity of Colistin against Heteroresistant Acinetobacter baumannii and Emergence of Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model{triangledown}

Chun-Hong Tan, Jian Li, and Roger L. Nation*

Facility for Anti-infective Drug Development and Innovation, Victorian College of Pharmacy, Monash University, Victoria 3052, Australia

Received 18 December 2006/ Returned for modification 7 March 2007/ Accepted 30 June 2007

Three clinically relevant intermittent regimens, and a continuous infusion, of colistin were simulated in an in vitro pharmacokinetic/pharmacodynamic model against two colistin-heteroresistant strains of Acinetobacter baumannii. Extensive initial killing was followed by regrowth as early as 6 h later; bacterial density in the 24- to 72-h period was within 1 log10 CFU/ml of growth control. Population analysis profiles revealed extensive emergence of resistant subpopulations regardless of the colistin regimen.

* Corresponding author. Mailing address: Facility for Anti-infective Drug Development and Innovation, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. Phone: 61 3 9903 9061. Fax: 61 3 9903 9629. E-mail: roger.nation{at}vcp.monash.edu.au

{triangledown} Published ahead of print on 9 July 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3413-3415, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.01571-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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