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Antimicrobial Agents and Chemotherapy, September 2007, p. 3416-3419, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00196-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Histatin-Derived Monomeric and Dimeric Synthetic Peptides Show Strong Bactericidal Activity towards Multidrug-Resistant Staphylococcus aureus In Vivo{triangledown}

Mick M. Welling,1* Carlo P. J. M. Brouwer,2 Wim van 't Hof,3 Enno C. I. Veerman,3 and Arie V. Nieuw Amerongen3

Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands,1 R&D, AM-Pharma, Bunnik, the Netherlands,2 Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral Biochemistry, Amsterdam, the Netherlands3

Received 9 February 2007/ Returned for modification 4 April 2007/ Accepted 27 June 2007

Homodimerization of histatin-derived peptides generally led to improved bactericidal activity against Staphylococcus aureus in vitro. In vivo, monomers and dimers were equally active in killing bacteria in mice with a soft tissue infection. Altogether, these peptides are promising compounds for the development of novel therapeutics against infections with drug-resistant bacteria.

* Corresponding author. Mailing address: Section Nuclear Medicine, Division of Radiology, Leiden University Medical Center, Room C4-R-77, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Phone: 31 71 5261880. Fax: 31 71 5266751. E-mail: m.m.welling{at}lumc.nl

{triangledown} Published ahead of print on 9 July 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3416-3419, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00196-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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