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Antimicrobial Agents and Chemotherapy, September 2007, p. 3445-3448, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00559-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Characterization of a Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Strain in a Patient with Endocarditis

Pennsylvania State University Milton S. Hershey Medical Center, Hershey, Pennsylvania,¹ Combinature Biopharm AG, Berlin, Germany,² Cubist Pharmaceuticals, Lexington, Massachusetts,³ Laboratory Specialists, Inc., Westlake, Ohio⁴

Received 28 April 2007/ Returned for modification 1 June 2007/ Accepted 2 July 2007

We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O-acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene.

Published ahead of print on 9 July 2007.

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