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Antimicrobial Agents and Chemotherapy, September 2007, p. 3445-3448, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00559-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Characterization of a Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Strain in a Patient with Endocarditis{triangledown}

Kathleen Julian,1* Klaudia Kosowska-Shick,1 Cynthia Whitener,1 Martin Roos,2 Harald Labischinski,2 Aileen Rubio,3 Leslie Parent,1 Lois Ednie,1 Laura Koeth,4 Tatiana Bogdanovich,1 and Peter C. Appelbaum1

Pennsylvania State University Milton S. Hershey Medical Center, Hershey, Pennsylvania,1 Combinature Biopharm AG, Berlin, Germany,2 Cubist Pharmaceuticals, Lexington, Massachusetts,3 Laboratory Specialists, Inc., Westlake, Ohio4

Received 28 April 2007/ Returned for modification 1 June 2007/ Accepted 2 July 2007

We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O-acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene.

* Corresponding author. Mailing address: Penn State Milton S. Hershey Medical Center, Room C6833, BMR Bldg., Mailcode H036, 500 University Dr., Hershey, PA 17033. Phone: (717) 531-8881. Fax: (717) 531-4633. E-mail: kjulian{at}psu.edu

{triangledown} Published ahead of print on 9 July 2007.

Antimicrobial Agents and Chemotherapy, September 2007, p. 3445-3448, Vol. 51, No. 9
0066-4804/07/$08.00+0     doi:10.1128/AAC.00559-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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