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Antimicrobial Agents and Chemotherapy, January 2008, p. 198-203, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00612-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Inhibition of Quorum Sensing-Controlled Virulence Factor Production in Pseudomonas aeruginosa by South Florida Plant Extracts{triangledown}

Allison Adonizio,1 Kok-Fai Kong,1,{dagger} and Kalai Mathee1,2*

Department of Biological Sciences,1 Department of Molecular Microbiology and Immunology, Florida International University, Miami, Florida 331992

Received 9 May 2007/ Returned for modification 12 July 2007/ Accepted 5 October 2007

Quorum sensing (QS) is a key regulator of virulence and biofilm formation in Pseudomonas aeruginosa and other medically relevant bacteria. Aqueous extracts of six plants, Conocarpus erectus, Chamaesyce hypericifolia, Callistemon viminalis, Bucida buceras, Tetrazygia bicolor, and Quercus virginiana, were examined in this study for their effects on P. aeruginosa virulence factors and the QS system. C. erectus, B. buceras, and C. viminalis caused a significant inhibition of LasA protease, LasB elastase, pyoverdin production, and biofilm formation. Additionally, each plant presented a distinct effect profile on the las and rhl QS genes and their respective signaling molecules, suggesting that different mechanisms are responsible for efficacy. Extracts of all plants caused the inhibition of QS genes and QS-controlled factors, with marginal effects on bacterial growth, suggesting that the quorum-quenching mechanisms are unrelated to static or cidal effects.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, College of Medicine, Florida International University, HLS673A, University Park, Miami, FL 33199. Phone: (305) 348-1261. Fax: (305) 348-2913. E-mail: matheek{at}fiu.edu

{triangledown} Published ahead of print on 15 October 2007.

{dagger} Current address: Department of Internal Medicine, Division of Rheumatology, Yale School of Medicine, New Haven, CT 06520.

Antimicrobial Agents and Chemotherapy, January 2008, p. 198-203, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00612-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Shepherd, R. W., Lindow, S. E. (2009). Two Dissimilar N-Acyl-Homoserine Lactone Acylases of Pseudomonas syringae Influence Colony and Biofilm Morphology. Appl. Environ. Microbiol. 75: 45-53 [Abstract] [Full Text]  
  • Adonizio, A., Leal, S. M. Jr, Ausubel, F. M., Mathee, K. (2008). Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system. J Med Microbiol 57: 809-813 [Abstract] [Full Text]  


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