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Antimicrobial Agents and Chemotherapy, January 2008, p. 333-336, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00689-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Activity of Meropenem with and without Ciprofloxacin and Colistin against Pseudomonas aeruginosa and Acinetobacter baumannii{triangledown} ,{dagger}

Glenn A. Pankuch,1 Gengrong Lin,1 Harald Seifert,2 and Peter C. Appelbaum1*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 University of Cologne, Cologne, Germany2

Received 25 May 2007/ Returned for modification 5 August 2007/ Accepted 18 October 2007

Time-kill synergy studies showed that at 24 h, subinhibitory meropenem and ciprofloxacin concentrations of 0.06 to 128 and 0.03 to 32 µg/ml, respectively, showed synergy against 34/51 Pseudomonas aeruginosa strains; subinhibitory concentrations of meropenem (0.06 to 8 µg/ml) and colistin (0.12 to 1 µg/ml) showed synergy against 13 isolates. Subinhibitory meropenem and ciprofloxacin concentrations of 0.25 to 2 and 0.12 to 16 µg/ml, respectively, showed synergy against 18/52 Acinetobacter baumannii strains at 24 h. Subinhibitory meropenem and colistin concentrations of 0.03 to 64 and 0.06 to 8 µg/ml, respectively, showed synergy against 49 strains at 24 h.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 29 October 2007.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, January 2008, p. 333-336, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00689-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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