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Antimicrobial Agents and Chemotherapy, January 2008, p. 337-339, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00939-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Fitness Cost and Impaired Survival in Penicillin-Resistant Streptococcus gordonii Isolates Selected in the Laboratory{triangledown} ,{dagger}

Marisa Haenni and Philippe Moreillon*

Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland

Received 20 July 2007/ Returned for modification 15 August 2007/ Accepted 30 October 2007

Cycling of Streptococcus gordonii (115 times) with penicillin resulted in a MIC increase of more than 100-fold, from 0.008 to 2 µg/ml. The 2-µg/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles.

* Corresponding author. Mailing address: Department of Fundamental Microbiology, Quartier UNIL-Sorge, Biophore Building, CH-1015 Lausanne, Switzerland. Phone: 41.21.692.56.01/00. Fax: 41.21.692.56.05. E-mail: philippe.moreillon{at}unil.ch

{triangledown} Published ahead of print on 12 November 2007.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, January 2008, p. 337-339, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00939-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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