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Fitness Cost and Impaired Survival in Penicillin-Resistant Streptococcus gordonii Isolates Selected in the Laboratory ^,

Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland

Received 20 July 2007/ Returned for modification 15 August 2007/ Accepted 30 October 2007

Cycling of Streptococcus gordonii (115 times) with penicillin resulted in a MIC increase of more than 100-fold, from 0.008 to 2 µg/ml. The 2-µg/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles.

Published ahead of print on 12 November 2007.

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