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Antimicrobial Agents and Chemotherapy, January 2008, p. 351-352, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00766-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Colistin Heteroresistance in Acinetobacter and Its Association with Previous Colistin Therapy{triangledown}

Joshua S. Hawley,1 Clinton K. Murray,1* and James H. Jorgensen2

Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas,1 Department of Pathology, University of Texas Health Science Center, San Antonio, Texas2

Received 14 June 2007/ Returned for modification 22 August 2007/ Accepted 8 October 2007

Colistin heteroresistance has been reported among Acinetobacter isolates; however, its association with prior colistin therapy has not been not described. A population analysis profile identified resistant Acinetobacter subpopulations from colistin-susceptible clinical isolates. The proportion of cells exhibiting heteroresistance was significantly higher among isolates recovered from patients treated with colistin.

* Corresponding author. Mailing address: Infectious Disease Service (MCHE-MDI-7E), Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234. Phone: (210) 916-4355. Fax: (210) 916-0388. E-mail: Clinton.Murray{at}amedd.army.mil

{triangledown} Published ahead of print on 22 October 2007.

Antimicrobial Agents and Chemotherapy, January 2008, p. 351-352, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00766-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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