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Antimicrobial Agents and Chemotherapy, January 2008, p. 357-360, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00856-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Differential Activities of Newer Antifungal Agents against Candida albicans and Candida parapsilosis Biofilms{triangledown}

Aspasia Katragkou,1 Athanasios Chatzimoschou,1 Maria Simitsopoulou,1 Maria Dalakiouridou,1 Eudoxia Diza-Mataftsi,2 Chaido Tsantali,3 and Emmanuel Roilides1*

Laboratory of Infectious Diseases, Third Department of Pediatrics, Aristotle University, Hippokration Hospital, 54642 Thessaloniki, Greece,1 First Department of Microbiology, Aristotle University, University Campus, 54124 Thessaloniki, Greece,2 First Department of Pediatrics, Aristotle University, Hippokration Hospital, 54642 Thessaloniki, Greece3

Received 29 June 2007/ Returned for modification 21 August 2007/ Accepted 6 October 2007

The activities of voriconazole, posaconazole, caspofungin, and anidulafungin against Candida albicans and Candida parapsilosis biofilms were evaluated. In contrast to planktonic cells, the MICs for voriconazole and posaconazole for the biofilms of the two species were high (≥256 and >64 mg/liter, respectively) but relatively low for the echinocandins caspofungin and anidulafungin (≤1 and ≤2 mg/liter, respectively).

* Corresponding author. Mailing address: Third Department of Pediatrics, Hippokration Hospital, Konstantinoupoleos 49, GR-546 42 Thessaloniki, Greece. Phone: 30-2310-892444. Fax: 30-2310-992981. E-mail: roilides{at}med.auth.gr

{triangledown} Published ahead of print on 15 October 2007.

Antimicrobial Agents and Chemotherapy, January 2008, p. 357-360, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00856-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Bland, C. M, Thomas, S. (2009). Micafungin plus Fluconazole in an Infected Knee with Retained Hardware due to Candida albicans. The Annals of Pharmacotherapy 43: 528-531 [Abstract] [Full Text]  
  • Jacobson, M. J., Piper, K. E., Nguyen, G., Steckelberg, J. M., Patel, R. (2008). In Vitro Activity of Anidulafungin against Candida albicans Biofilms. Antimicrob. Agents Chemother. 52: 2242-2243 [Abstract] [Full Text]  


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