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Antimicrobial Agents and Chemotherapy, January 2008, p. 365-373, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00910-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Comparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis{triangledown}

Kim L. Credito, Lois M. Ednie, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 11 July 2007/ Returned for modification 2 September 2007/ Accepted 8 October 2007

Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC50 of 0.125 µg/ml and an MIC90 of 1 µg/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2x MIC after 48 h.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 15 October 2007.

Antimicrobial Agents and Chemotherapy, January 2008, p. 365-373, Vol. 52, No. 1
0066-4804/08/$08.00+0     doi:10.1128/AAC.00910-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cirillo, I., Vaccaro, N., Turner, K., Solanki, B., Natarajan, J., Redman, R. (2009). Pharmacokinetics, Safety, and Tolerability of Doripenem After 0.5-, 1-, and 4-Hour Infusions in Healthy Volunteers. J Clin Pharmacol 49: 798-806 [Abstract] [Full Text]  
  • Ednie, L. M., Appelbaum, P. C. (2009). Antianaerobic Activity of Sulopenem Compared to Six Other Agents. Antimicrob. Agents Chemother. 53: 2163-2170 [Abstract] [Full Text]  


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