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Antimicrobial Agents and Chemotherapy, October 2008, p. 3779-3782, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.01665-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Edelfosine Induces an Apoptotic Process in Leishmania infantum That Is Regulated by the Ectopic Expression of Bcl-XL and Hrk{triangledown}

Juan Fernando Alzate,1 Andrés Arias,2 Faustino Mollinedo,3 Eva Rico,2 Janis de la Iglesia-Vicente,3 and Antonio Jiménez-Ruiz2*

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia,1 Departamento de Bioquímica y Biología Molecular, Campus Universitario, Universidad de Alcalá, Alcalá de Henares, Madrid 28871, Spain,2 Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca E-37007, Spain3

Received 25 December 2007/ Returned for modification 25 March 2008/ Accepted 7 July 2008

The alkyl-lysophospholipids edelfosine and miltefosine induce apoptosis in Leishmania infantum promastigotes. The finding that edelfosine-induced cell death can be regulated by the ectopic expression of the antiapoptotic and proapoptotic members of the Bcl-2 family of proteins Bcl-XL and Hrk suggests that this process is similar to apoptosis in eukaryotic cells.

* Corresponding author. Mailing address: Departamento de Bioquímica y Biología Molecular, Campus Universitario, Universidad de Alcalá, Alcalá de Henares 28871, Madrid, Spain. Phone: (34)918855109. Fax: (34)918854585. E-mail: antonio.jimenez{at}uah.es

{triangledown} Published ahead of print on 21 July 2008.

Antimicrobial Agents and Chemotherapy, October 2008, p. 3779-3782, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.01665-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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