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Antimicrobial Agents and Chemotherapy, October 2008, p. 3783-3785, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00473-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Development of Caspofungin Resistance following Prolonged Therapy for Invasive Candidiasis Secondary to Candida glabrata Infection{triangledown}

George R. Thompson III,1* Nathan P. Wiederhold,1,3,4 Ana C. Vallor,1 Nyria C. Villareal,1 James S. Lewis II,1,2 and Thomas F. Patterson1

University of Texas Health Science Center at San Antonio, Department of Internal Medicine, Division of Infectious Diseases, MSC 7881, 7703 Floyd Curl Drive, San Antonio, Texas 78229,1 Department of Pharmacy, University Health System, San Antonio, Texas 78229,2 University of Texas at Austin College of Pharmacy, 1 University Station, A1900, Austin, Texas 78712,3 University of Texas Health Science Center at San Antonio, Pharmacotherapy Education and Research Center, MSC 6220, 7703 Floyd Curl Drive, San Antonio, Texas 782994

Received 9 April 2008/ Returned for modification 23 June 2008/ Accepted 20 July 2008

We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.

* Corresponding author. Mailing address: Department of Internal Medicine, Division of Infectious Diseases, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229. Phone: (210) 567-6680. Fax: (210) 567-3303. E-mail: thompsong2{at}uthscsa.edu

{triangledown} Published ahead of print on 1 August 2008.

Antimicrobial Agents and Chemotherapy, October 2008, p. 3783-3785, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00473-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Garcia-Effron, G., Lee, S., Park, S., Cleary, J. D., Perlin, D. S. (2009). Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3-{beta}-D-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint. Antimicrob. Agents Chemother. 53: 3690-3699 [Abstract] [Full Text]  
  • Katiyar, S. K., Edlind, T. D. (2009). Role for Fks1 in the Intrinsic Echinocandin Resistance of Fusarium solani as Evidenced by Hybrid Expression in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 53: 1772-1778 [Abstract] [Full Text]  


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