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Antimicrobial Agents and Chemotherapy, October 2008, p. 3789-3791, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00479-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evolution of the ISCR3 Group of ISCR Elements{triangledown}

Mark A. Toleman* and Timothy R. Walsh

Department of Medical Microbiology, School of Medicine, University of Cardiff, Cardiff CF14 4XN, United Kingdom

Received 11 April 2008/ Returned for modification 15 June 2008/ Accepted 20 July 2008

The ISCR elements ISCR3, ISCR4, ISCR5, ISCR14, and ISCR16 all share a percent G+C of 68 to 69%. They also share between 75% and 97% identity in their transposase open reading frames. Furthermore, with the exception of ISCR5, they are all found adjacent to sections of groEL that display the highest identity to the same gene from Xanthomonas spp. The combined information is consistent with the descent from an ancestral ISCR element in a Xanthomonas-like organism.

* Corresponding author. Mailing address: School of Medicine, Dept. of Medical Microbiology, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom. Phone: 44 (0) 29 2074 3129. Fax: 44 (0) 29 2074 2161. E-mail: TolemanMA{at}Cardiff.ac.uk

{triangledown} Published ahead of print on 28 July 2008.

Antimicrobial Agents and Chemotherapy, October 2008, p. 3789-3791, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00479-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Li, H., Walsh, T. R., Toleman, M. A. (2009). Molecular Analysis of the Sequences Surrounding blaOXA-45 Reveals Acquisition of This Gene by Pseudomonas aeruginosa via a Novel ISCR Element, ISCR5. Antimicrob. Agents Chemother. 53: 1248-1251 [Abstract] [Full Text]  


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