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Antimicrobial Agents and Chemotherapy, October 2008, p. 3792-3794, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00387-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant β-Lactamase from Klebsiella pneumoniae{triangledown}

Véronique Dubois,1* Laurent Poirel,2 François Demarthe,1 Corinne Arpin,1 Laure Coulange,1 Luciene A. R. Minarini,2 Marie-Christine Bezian,3 Patrice Nordmann,2 and Claudine Quentin1

UMR 5234, CNRS, Université de Bordeaux 2, Bordeaux,1 Service de Bactériologie-Virologie, INSERM U914: Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre,2 Laboratoire de Bactériologie, Hôpital Saint-André, Bordeaux, France3

Received 21 March 2008/ Returned for modification 22 May 2008/ Accepted 23 July 2008

A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene blaSHV-56, encoding a new inhibitor-resistant β-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.

* Corresponding author. Mailing address: Laboratoire de Microbiologie, UMR-CNRS 5234, Université de Bordeaux 2, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France. Phone: 33 5 57 57 10 75. Fax: 33 5 56 90 90 72. E-mail: veronique.dubois{at}bacterio.u-bordeaux2.fr

{triangledown} Published ahead of print on 28 July 2008.

Antimicrobial Agents and Chemotherapy, October 2008, p. 3792-3794, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00387-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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