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Antimicrobial Agents and Chemotherapy, October 2008, p. 3795-3800, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00464-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Fluoroquinolone Enhances the Mutation Frequency for Meropenem-Selected Carbapenem Resistance in Pseudomonas aeruginosa, but Use of the High-Potency Drug Doripenem Inhibits Mutant Formation{triangledown}

Koichi Tanimoto,2 Haruyoshi Tomita,1 Shuhei Fujimoto,1 Katsuko Okuzumi,3 and Yasuyoshi Ike1,2*

Department of Bacteriology,1 Laboratory of Bacterial Drug Resistance, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan,2 Department of Medical Safety Administration Division of Infection Control, Dokkyo Medical University Hospital, Shimotsuga, Tochigi 321-0293, Japan3

Received 8 April 2008/ Returned for modification 22 May 2008/ Accepted 4 August 2008

The mutation frequency for carbapenem resistance in Pseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increased mexAB-oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.

* Corresponding author. Mailing address: Department of Bacteriology, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, Gunma 371-8511, Japan. Phone: 81-27-220-7990. Fax: 81-27-220-7996. E-mail: yasuike{at}med.gunma-u.ac.jp

{triangledown} Published ahead of print on 11 August 2008.

Antimicrobial Agents and Chemotherapy, October 2008, p. 3795-3800, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00464-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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