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Antimicrobial Agents and Chemotherapy, October 2008, p. 3810-3813, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00233-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Mutator Genes Giving Rise to Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa{triangledown}

Irith Wiegand, Alexandra K. Marr, Elena B. M. Breidenstein, Kristen N. Schurek, Patrick Taylor, and Robert E. W. Hancock*

Centre for Microbial Diseases and Immunity Research, Room 232, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4

Received 20 February 2008/ Returned for modification 11 April 2008/ Accepted 23 July 2008

Screening of the PA14 genomic transposon mutant library for resistance to ceftazidime, tobramycin, and ciprofloxacin led to the discovery of several mutants that appeared in more than one screen. Testing of the frequency of mutation to ciprofloxacin resistance revealed previously known mutator genes, including mutS and mutL, as well as mutators that have not yet been described for P. aeruginosa, including PA3958 and RadA (PA4609).

* Corresponding author. Mailing address: Centre for Microbial Diseases and Immunity Research, Room 232, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4. Phone: (604) 822 2682. Fax: (604) 827 5566. E-mail: bob{at}cmdr.ubc.ca

{triangledown} Published ahead of print on 28 July 2008.

Antimicrobial Agents and Chemotherapy, October 2008, p. 3810-3813, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00233-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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  • Dotsch, A., Becker, T., Pommerenke, C., Magnowska, Z., Jansch, L., Haussler, S. (2009). Genomewide Identification of Genetic Determinants of Antimicrobial Drug Resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 53: 2522-2531 [Abstract] [Full Text]  
  • Schurek, K. N., Marr, A. K., Taylor, P. K., Wiegand, I., Semenec, L., Khaira, B. K., Hancock, R. E. W. (2008). Novel Genetic Determinants of Low-Level Aminoglycoside Resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 52: 4213-4219 [Abstract] [Full Text]  


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