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Antimicrobial Agents and Chemotherapy, October 2008, p. 3823-3825, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00026-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Smqnr, a New Chromosome-Carried Quinolone Resistance Gene in Stenotrophomonas maltophilia{triangledown}

Kenichiro Shimizu, Ken Kikuchi,* Takashi Sasaki, Namiko Takahashi, Masayuki Ohtsuka, Yuka Ono, and Keiichi Hiramatsu

Department of Infection Control Science, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan

Received 8 January 2008/ Returned for modification 28 February 2008/ Accepted 12 July 2008

A new chromosome-carried quinolone resistance gene from Stenotrophomonas maltophilia, Smqnr, was characterized. The gene was present in type strain CCUG 5866 and was also detected in 24 clinical isolates and showed some allelic diversity. The expression of Smqnr in Escherichia coli decreased the susceptibilities of the E. coli isolates to several fluoroquinolones.

* Corresponding author. Mailing address: Department of Infection Control Science, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Phone: 81-3-5802-1041. Fax: 81-3-5684-7830. E-mail: kikuti{at}juntendo.ac.jp

{triangledown} Published ahead of print on 21 July 2008.

Antimicrobial Agents and Chemotherapy, October 2008, p. 3823-3825, Vol. 52, No. 10
0066-4804/08/$08.00+0     doi:10.1128/AAC.00026-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Strahilevitz, J., Jacoby, G. A., Hooper, D. C., Robicsek, A. (2009). Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat. Clin. Microbiol. Rev. 22: 664-689 [Abstract] [Full Text]  
  • Wang, M., Guo, Q., Xu, X., Wang, X., Ye, X., Wu, S., Hooper, D. C., Wang, M. (2009). New Plasmid-Mediated Quinolone Resistance Gene, qnrC, Found in a Clinical Isolate of Proteus mirabilis. Antimicrob. Agents Chemother. 53: 1892-1897 [Abstract] [Full Text]  


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