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Antimicrobial Agents and Chemotherapy, November 2008, p. 3905-3908, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00653-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro and In Vivo Evaluations of Oxacillin Efficiency against mecA-Positive Oxacillin-Susceptible Staphylococcus aureus{triangledown}

Alexandros Ikonomidis,1 George Michail,1 Afroditi Vasdeki,1 Maria Labrou,1 Vasilis Karavasilis,1 Constantinos Stathopoulos,2 Antonios N. Maniatis,1 and Spyros Pournaras1*

Department of Microbiology, School of Medicine,1 Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, Larissa, Greece2

Received 17 May 2008/ Returned for modification 21 June 2008/ Accepted 5 August 2008

Community-type Staphylococcus aureus strains that are positive for mecA and PBP2a but appear phenotypically susceptible to oxacillin are increasingly reported worldwide. Four S. aureus clinical isolates carrying the mecA gene with oxacillin MICs of <2 µg/ml were tested for oxacillin efficiency by population analyses and experimental thigh infections. These isolates harbored staphylococcal cassette chromosome mec type IV and belonged to two genotypes. Two of the four isolates were found by population analysis to be truly oxacillin susceptible. All four isolates exhibited significant reductions in the numbers of colonies grown after dicloxacillin treatment of experimental thigh infections, as also did a mecA-negative S. aureus control strain. These observations indicate that some of the phenotypically oxacillin susceptible mecA-positive Staphylococcus aureus isolates may be at least partially responsive to oxacillin.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Hospital of Larissa, Mezourlo, 411 10 Larissa, Greece. Phone: 30 2410 682929. Fax: 30 2410 681570. E-mail: pournaras{at}med.uth.gr

{triangledown} Published ahead of print on 11 August 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 3905-3908, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00653-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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