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Antimicrobial Agents and Chemotherapy, November 2008, p. 4064-4068, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00725-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Assessing the Efficacy of Cidofovir against Herpesvirus-Induced Genital Lesions in Goats Using Different Therapeutic Regimens{triangledown}

M. Tempesta,1* G. Crescenzo,1 M. Camero,1 A. L. Bellacicco,1 E. Tarsitano,1 N. Decaro,1 J. Neyts,2 V. Martella,1 and C. Buonavoglia1

Department of Public Health and Animal Sciences, Faculty of Veterinary Medicine, University of Bari, Valenzano, Italy,1 Rega Institute for Medical Research, Leuven, Belgium2

Received 3 June 2008/ Returned for modification 25 July 2008/ Accepted 26 August 2008

Caprine herpesvirus 1 (CpHV-1) infection in goats induces genital vesicular-ulcerative lesions that strictly resemble those produced by human herpesvirus 2 in humans. In previous studies, the potent inhibition of CpHV-1 by cidofovir was demonstrated. Cidofovir antiherpetic activity was evaluated in goats infected experimentally by the vaginal route with CpHV-1 and then treated locally at different times after infection. The administration of 1% cidofovir cream onto vaginal mucosa was able to prevent the onset of genital lesions and to decrease significantly the titers of the virus shed by the infected animals, notably in the groups treated shortly after infection (24 and 48 h). The efficacy of cidofovir against caprine herpesvirus infection was higher when the treatment was started shortly after infection than when lesions were already present and advanced. Herpesvirus genital infection of goats is a useful animal model to study the activity of antiviral drugs against human herpesvirus infections.

* Corresponding author. Mailing address: Department of Public Health and Animal Sciences, Faculty of Veterinary Medicine, University of Bari, Sp Casamassima km. 3, 70010 Valenzano (BA), Italy. Phone: 39 080 4679838. Fax: 39 080 4679843. E-mail: m.tempesta{at}veterinaria.uniba.it

{triangledown} Published ahead of print on 2 September 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4064-4068, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00725-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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