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Antimicrobial Agents and Chemotherapy, November 2008, p. 4149-4152, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00509-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Piperacillin-Tazobactam Penetration into Human Pancreatic Juice{triangledown}

Elisa Bertazzoni Minelli,1* Anna Benini,1 Luigina Franco,1 Claudio Bassi,2 and Paolo Pederzoli2

Departments of Medicine and Public Health, Pharmacology Section,1 Surgical and Gastroenterological Sciences, University of Verona, Verona, Italy2

Received 18 April 2008/ Returned for modification 2 July 2008/ Accepted 9 September 2008

Piperacillin-tazobactam was administered as a single dose (4.5 g intravenous) to five patients with stabilized external pancreatic fistula. The penetration into pancreatic juice was prompt, and inhibitory concentrations were achieved and maintained for different periods (0.5 to 6 h) according to bacterial susceptibility and patients' characteristics. Piperacillin and tazobactam showed superimposable pharmacokinetics in both serum and pancreatic juice.

* Corresponding author. Mailing address: Department of Medicine and Public Health, Pharmacology Section, Policlinico G. B. Rossi, P.le LA Scuro, 37134 Verona, Italy. Phone: 39 045 8027603. Fax: 39 045 8027452. E-mail: elisa.bertazzoni{at}univr.it

{triangledown} Published ahead of print on 22 September 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4149-4152, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00509-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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