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Antimicrobial Agents and Chemotherapy, November 2008, p. 4163-4165, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00476-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of OPT-80 Tested against Clinical Isolates of Toxin-Producing Clostridium difficile{triangledown}

James A. Karlowsky,* Nancy M. Laing, and George G. Zhanel

Department of Medical Microbiology and Infectious Diseases, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Received 10 April 2008/ Returned for modification 2 August 2008/ Accepted 15 August 2008

Agar dilution antimicrobial susceptibility testing (CLSI, M11-A7, 2007) performed for 208 toxin-producing clinical isolates of Clostridium difficile resulted in OPT-80 MICs ranging from 0.06 to 1 µg/ml, with 90% of the isolates inhibited by a concentration of 0.5 µg/ml. The in vitro activity of OPT-80 was independent of the susceptibilities of isolates to nine other antimicrobial agents.

* Corresponding author. Mailing address: Department of Clinical Microbiology, Health Sciences Centre, MS673C, 820 Sherbrook Street, Winnipeg, Manitoba, R3A 1R9, Canada. Phone: (204) 787-4597. Fax: (204) 787-4699. E-mail: jkarlowsky{at}hsc.mb.ca

{triangledown} Published ahead of print on 25 August 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4163-4165, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00476-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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