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Antimicrobial Agents and Chemotherapy, November 2008, p. 4181-4183, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00802-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Caspofungin-Resistant Candida tropicalis Strains Causing Breakthrough Fungemia in Patients at High Risk for Hematologic Malignancies{triangledown}

Guillermo Garcia-Effron,1 Dimitrios P. Kontoyiannis,2* Russell E. Lewis,2 and David S. Perlin1*

Public Health Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey,1 The University of Texas M. D. Anderson Cancer Center, Houston, Texas2

Received 18 June 2008/ Returned for modification 23 August 2008/ Accepted 7 September 2008

We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid substitution within Fks1p hot spot 1.

* Corresponding author. Mailing address for Dimitrios P. Kontoyiannis: Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030. Phone: (713) 792-6237. Fax: (713) 745-6839. E-mail: dkontoyi{at}mdanderson.org. Mailing address for David S. Perlin: Public Health Research Institute, 225 Warren Street, Newark, NJ 07103. Phone: (973) 854-3200. Fax: (973) 854-3101. E-mail: perlinds{at}umdnj.edu

{triangledown} Published ahead of print on 15 September 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4181-4183, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00802-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Garcia-Effron, G., Lee, S., Park, S., Cleary, J. D., Perlin, D. S. (2009). Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3-{beta}-D-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint. Antimicrob. Agents Chemother. 53: 3690-3699 [Abstract] [Full Text]  
  • Katiyar, S. K., Edlind, T. D. (2009). Role for Fks1 in the Intrinsic Echinocandin Resistance of Fusarium solani as Evidenced by Hybrid Expression in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 53: 1772-1778 [Abstract] [Full Text]  


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