This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Duesberg, C. B.
Right arrow Articles by Pletz, M. W. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duesberg, C. B.
Right arrow Articles by Pletz, M. W. R.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2008, p. 4191-4193, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00518-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Interspecies Recombination Occurs Frequently in Quinolone Resistance-Determining Regions of Clinical Isolates of Streptococcus pyogenes{triangledown}

Christoph B. Duesberg,1 Surbhi Malhotra-Kumar,2 Herman Goossens,2 Lesley McGee,3 Keith P. Klugman,3,4 Tobias Welte,1 and Mathias W. R. Pletz1*

Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany,1 Department of Medical Microbiology, Vaccine & Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium,2 Hubert Department of Global Health, Rollins School of Public Health, Atlanta, Georgia,3 Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia4

Received 22 April 2008/ Returned for modification 5 June 2008/ Accepted 21 August 2008

Fluoroquinolone resistance in Streptococcus pyogenes has been reported only anecdotally, but a recent Belgian surveillance study found a rate of nonsusceptibility of 5.4%. From an analysis of these isolates, we show that interspecies horizontal gene transfer within the parC quinolone resistance-determining region is a frequent phenomenon that might contribute to fluoroquinolone resistance.

* Corresponding author. Mailing address: Department of Respiratory Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany. Phone: 49 511 532 3661. Fax: 49 511 532 9674 3353. E-mail: pletz.mathias{at}mh-hannover.de

{triangledown} Published ahead of print on 2 September 2008.

Antimicrobial Agents and Chemotherapy, November 2008, p. 4191-4193, Vol. 52, No. 11
0066-4804/08/$08.00+0     doi:10.1128/AAC.00518-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wolter, N., du Plessis, M., von Gottberg, A., de Gouveia, L., Klugman, K. P. (2009). Molecular Characterization of Emerging Non-Levofloxacin-Susceptible Pneumococci Isolated from Children in South Africa. J. Clin. Microbiol. 47: 1319-1324 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»