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Antimicrobial Agents and Chemotherapy, December 2008, p. 4463-4465, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00810-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Lysine-Enriched Cecropin-Mellitin Antimicrobial Peptides with Enhanced Selectivity {triangledown}

Hiromi Sato1 and Jimmy B. Feix2*

Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Disease,1 Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 532262

Received 19 June 2008/ Returned for modification 4 August 2008/ Accepted 7 October 2008

Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA1-7 M2-9 (designated CM15), designed with optimized amphipathicity, retained antimicrobial activities similar to that of wild-type CM15 and had substantially reduced levels of hemolytic activity and cytotoxicity toward cultured macrophages, resulting in enhanced selectivity. These lysine-enriched analogs provide templates for improved CM15 peptide or peptidomimetic antibiotics.

* Corresponding author. Mailing address: Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226. Phone: (414) 456-4037. Fax: (414) 456-6512. E-mail: jfeix{at}mcw.edu

{triangledown} Published ahead of print on 13 October 2008.

Antimicrobial Agents and Chemotherapy, December 2008, p. 4463-4465, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00810-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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