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Antimicrobial Agents and Chemotherapy, December 2008, p. 4466-4469, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00903-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Inhibition of Toxoplasma gondii by Indirubin and Tryptanthrin Analogs {triangledown}

Bogdana Krivogorsky,1,{dagger} Peter Grundt,2,{dagger} Robert Yolken,1* and Lorraine Jones-Brando1

Stanley Laboratory, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland,1 Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota2

Received 8 July 2008/ Returned for modification 4 August 2008/ Accepted 22 September 2008

New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.

* Corresponding author. Mailing address: Dept. of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287. Phone: (410) 614-0004. Fax: (410) 955-3723. E-mail: rhyolken{at}aol.com

{triangledown} Published ahead of print on 29 September 2008.

{dagger} These individuals contributed equally to the manuscript.

Antimicrobial Agents and Chemotherapy, December 2008, p. 4466-4469, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00903-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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